Accession Number:

ADA135364

Title:

Studies in Boron Chemistry.

Descriptive Note:

Final rept. 1 Jul 80-30 Sep 83,

Corporate Author:

DUKE UNIV DURHAM NC PAUL M GROSS CHEMICAL LAB

Personal Author(s):

Report Date:

1983-11-15

Pagination or Media Count:

4.0

Abstract:

The exploration of the synthesis and characterization of isoelectronic and isostructural boron analogs of the alpha-amino acids, their precursors, and derivative was continued during this period. The boron analogs are very weak acids with pK1 approximately 8. They exhibit significant anti-arthritic, hypolipidemic, and antitumor activity. The chemistry and activity has been described in publications 1-9 and in patents and patent submissions 1-5.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE