Neurophysiological Bases of Event-Related Potentials.
Annual rept. no. 1, 1 May 82-30 Apr 83,
SRI INTERNATIONAL MENLO PARK CA LIFE SCIENCES DIV
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In order to more fully understand the physiological and psychological significance of event-related potentials, cortical and subcortical recordings are being obtained form monkeys performing in operant-conditioning tasks, Six animals were trained on initial phases of the cued reaction-time task at SRI International and were subsequently implanted with electrodes capable of recording transient and sustained evoked potentials and massed-unit activity. Two monkeys were trained on initial phases of an oddball task at Stanford University, and electrodes are being prepared so that the subcortical generators of the P300 wave can be assessed in these animals. An LSI-1123 computer system was installed at SRI to implement the cued reaction-time task and to collect event-related potentials. Preliminary recordings of slow potentials and massed-unit activity were collected from the lateral geniculate nucleus of one cat to evaluate the performance of modified amplifiers, and transient P300 and sustained contingent negative variation evoked potentials were recorded from the scalps of human subjects to confirm appropriate performance of the laboratory system. Author
- Anatomy and Physiology