Chemotherapy of Rodent Malaria. Evaluation of Drug Action against Normal and Resistant Strains including Exo-Erythrocytic Stages.
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (ENGLAND) DEPT OF PARASITOLOGY
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Research was designed to assist in finding solutions to the following problems 1 New compounds are needed for the prevention and treatment of malaria parasites that are resistant to chloroquine and other standard antimalarials, i.e., P. falciparum 2 Safer antirelapse drugs are needed to replace primaquine in the treatment of P. vivax infections 3 In order to open the way to the rational design of new antimalarials more needs to be known of the mode of action of existing compounds, and the manner in which the parasites can become resistant to them 4 In order to answer these questions we need to know more about the matabolic pathways of normal malaria parasites and 5 Ways of combining drug resistance by the use of drug combinations are required, especially as a means of preventing the further development of resistance to new compounds. The present report outlines the major steps taken to help study these problems and summarises the principle achievements of the period under review.