Accession Number:

ADA134407

Title:

Humoral Control of Regional Blood Flow in Hemorrhagic Shock in Non-Resuscitated and Resuscitated Animals.

Descriptive Note:

Annual rept. 1 May-31 Aug 82,

Corporate Author:

QUEEN'S MEDICAL CENTER HONOLULU HI CARDIOVASCULAR RESEARCH LAB

Personal Author(s):

Report Date:

1982-09-01

Pagination or Media Count:

97.0

Abstract:

In experiments in rabbits and primates we have 1 Reaffirmed a prolonged reduction in blood volume and visceral organ flow for periods of at least 18 hours after resuscitation from hemorrhagic shock. 2 Shown that none of the readily identifiable humoral controls of blood pressure or vascular resistance are involved in this flow redistribution i.e., reninangiotensin, cathecholamines, thromboxane. 3 Demonstrate improved survival in shocked rabbits treated with ATP-MgC12. 4 Failed to demonstrate any change in mortality in shocked animals subjected to endorphin antagonism with naloxone. 5 Shown no favorable effect of resuscitation with fluorocarbons on survival in rabbits in hemorrhagic shock.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE