The Mechanism of Microcirculatory Failure in Shock.
QUEEN'S MEDICAL CENTER HONOLULU HI CARDIOVASCULAR RESEARCH LAB
Pagination or Media Count:
Work has progressed in 3 areas 1 evaluating blood filtration, 2 assessment of shock in a rabbit and subsequently a baboon shock model, and 3 the influence of ischemia and shock blood in microvascular blood flow in an isolated limb perfusion system. We are currently halfway through a comprehensive in vitro evaluation of blood filters and are a year into a three-year project on the clinical evaluation of blood filters. After conducting two sets of experiments in a rabbit shock model, we completed a preliminary set of experiments on baboons in shock which has allowed us to refine the protocol and demonstrate the feasibility of treating baboons, following resuscitation from shock, with nitroprusside in an attempt to restore visceral organ blood flow more quickly to normal. We have established an isolated limb perfusion model in pigs and have completed one set of experiments showing an increase in vascular resistance in the limb perfused with shocked blood. We are planning to continue with isolated limb perfusion studies to try and define the role of the platelet in the genesis of these resistance changes. Author
- Anatomy and Physiology
- Medicine and Medical Research