Management of Hard Tissue Avulsive Wounds and Management of Orofacial Fractures.
Rept. no. 7 (Annual) 1 Aug 80-31 May 81,
BATTELLE COLUMBUS LABS OH
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Research studies were continued to further our understanding of the in vivo behavior of resorbable calcium phosphate ceramics for use in the management of hard tissue avulsive wounds and orofacial fractures. Material processing studies were conducted to develop porous tricalcium phosphate materials of directional porosity. An observation of the critical importance of pore directionality was made and reported in the last annual report. Consequently, a material with directional porosity was envisioned which would allow adequate ingrowth of bone through the biomaterial prior to loss of mechanical integrity of the biomaterial. Classically, porous biodegradable biomaterial designs have had omnidirectional pores which limit the strength of the biomaterial. A controlled unidirectional material is free from the above design constraint. Numerous possibilities are thus available. The overall objective is to produce a completely resorbable biomaterial which will promote bone formation and after the bone remodeling, biodegradation process be completely replace by bone. The specific objective of this study was to find a method of producing unidirectional porosity tricalcium phosphate material for large segment repair and then test the material in vivo.
- Medicine and Medical Research