Toxicological Assessment of ABATE (Trade Name) (0,0,0',0'-Tetramethyl-0,0'-Thio-Di-P-Phenylene Phosphorothioate) Administered Orally to Mated and Nonmated Female Rabbits, April 1983. Phase 3.
Interim rept. Sep 79-Aug 83,
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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This study was designed to assess the embryotoxic and teratologic potential of ABATE following repeated oral administration of the compound to pregnant rabbits during the period of gestation which spans organogenesis. Mated and nonmated animals were used in order to compare the toxic effects of ABATE in combination with the stress of pregnancy. These tests indicated no teratologic effects in New Zealand White Rabbits following repeated oral administration of ABATE at levels which produced a toxic effect. The stress of pregnancy did not produce an increased sensitivity to the compound. Although these studies have shown that ABATE should not cause teratologic effects in its intended use, chronic studies should be performed to further define any potential long term toxicity.