Dermal Toxicity of T-2 Toxin in Guinea Pigs, Rats, and Cynomolgus Monkeys
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
T-2 mycotoxins can cause a spectrum of injury from erythema through necrosis when exposed to the skin of various species. Of the species tested the skin of rabbit was most sensitive to the toxin, while that of the cynomologus monkey was the least. Skin absorption of this toxin appeared to be relatively slow with most liquid solvents in the three species studied, as compared to IM dosage. As observed with aflatoxin, a screen barrier was required to prevent oral ingestion and facial contamination of T-2 mycotoxin when applied to the skin, When a screen-barrier was utilized, very high doses of toxin were required in the guinea pig and cynomolgus monkey. DMSO appears to increase percutaneous absorption of T-2 in rat, however, it was not as effective in the guinea pig or monkey. The relationship to percutaneous absorption of T-2 mycotoxin through human skin will require additional studies which utilize in vitro model or human skin implants in the nude mouse. Soap and water wash appears to be an effective treatment for removal of toxin from the skin in most solvents. Additional data are required to determine what will be the maximum effective time of the toxin is applied in DMSO.