Pyridostigmine-Induced Cholinesterase Inhibition: Effects on the Ability to Work in the Heat,
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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Adult, male rats 300-325 g were treated with pyridostigmine bromide n22 or saline n22 to quantitate the effects of severe 64 cholinesterase inhibition on the ability to work 9.14 mmin, level treadmill in the heat 35 deg C. Pyridostigmine-treated rats had a mean endurance of 23 min while saline-treated animals ran for nearly 35 min por.001. Rates of rectal and skin temperature increments were significantly higher por.001 in pyridostigmine-treated rats as were water losses por.001. While exercise in the heat to hyperthermic exhaustion effected anticipated increments in circulating urea nitrogen, creatinine, lactate dehydrogenase, and potassium levels, pyridostigmine pretreatment had additive effects on lactate and creatine phosphokinase concentrations. Additionally, pyridostigmine effected a significant por.01 hyperglycemia prior to exercise. We concluded that pyridostigmine-induced cholinesterase inhibition had a variety of debilitating effects during work in the heat.
- Stress Physiology