Regulation of Chromatin Function by Polyadenosine Diphosphoribosylation,
CALIFORNIA UNIV SAN FRANCISCO
Pagination or Media Count:
The biological function of poly ADP-R based on its macromolecular properties is envisaged as a nucleic acid component of a cross linking system capable of promoting or inhibiting the regulatory effect of chromatin proteins on transcription. Two examples, the action of triiodothyronine and of chemical carcinogens illustrate this complex action of the homopolymer functioning as a protein modifier. Although DNA and RNA can be profitably studied in isolated systems without paying attention to poly ADP-R, integration with cellular physiology makes it mandatory to include poly ADP-R as a nucleic acid that possesses exclusively regulatory function.