Accession Number:

ADA129661

Title:

Lung Metabolism, Function, and Morphology during Hyperoxic and Hyperbaric Exposure

Descriptive Note:

Final technical rept. 1 Jan-31 Dec 1978

Corporate Author:

WISCONSIN UNIV-MADISON DEPT OF VETERINARY SCIENCE

Personal Author(s):

Report Date:

1983-01-01

Pagination or Media Count:

13.0

Abstract:

Indolamine 2,3 dioxygenase has been found in human lung this enzyme has potential as an important oxygen radical scavenger, MK421, is a non- sulfhydryl group angiotensin-converting-enzyme inhibitor which was found not to alter adrenergic responsiveness, Neuron-specific-enolase and 5-HT immunoreactive lung neuroendocrine cell populations are not the same in the fetal monkey lung implying that either development rates are not the same or more than one population is present, a possible genetic relationship between cytochrome P-450 enzyme induction and oxidative stress has been established implying that the susceptibility to oxygen toxicity may be inherited as well as environmental, Selenium and vitamin E deficiency may cause a decrease of the medial thickness in small pulmonary arteries implying that regulation of smooth muscle reactivity may be related to levels of organic hydroperoxides, lipid peroxidation, lipoxygenase or cyclooxygenase products, or a change in platelet activation status, The smallest subunit of Lipid A,Lipid X mol.wgt. 711 has been characterized and causes all of the physiological effects on the pulmonary circulation seen with complete endotoxin, and finally Venous dispersion of lung 5-HT uptake kinetics using the bolus injection technique were different when trace doses were superimposed on constant background concentrations.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE