Characterization of the Chemical Constitution and Profile of Pharmacological Activity of PGB(x).
Final rept. 1 Jan 79-31 Dec 82,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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The pharmacological studies conducted over the past four years have attempted to answer the following questions a Does PGBx produce organ level effects that are expressions of PGBxs established mitochondrial actions b Are the organ level effects related to PGBxs ability to act as a calcium iontophore c In assessing its potential therapeutic utility, are there other actions of PGBx that are relevant d Can an organ level bioassay be designed that is adapatble to the evaluation and comparison of biological activity of PGBx analogs and components The results of these studies are summarized.