Acute Clinical Malaria (Plasmodium inui) in a Cynomolgus Monkey (Macaca fascicularis)
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
Acute clinical malaria caused by Plasmodium inui was diagnosed in an adult female cynomolgus monkey Macaca fascicularis 4 years after importation into the United States. Stress and immunosuppression associated with experimentation completed 2 weeks earlier may have contributed to the development of severe clinical disease. Clinical findings included severe regenerative anemia, hepatosplenomegaly, weakness, lethargy, weight loss, and anorexia. The infection was treated and successfully eliminatd with chloquinie hydrochloride administered intramuscularly at a dose of 5 mgkg base given at 0, 6, 24, 48, and 72 hours. Treatment also included a blood transfusion and intensive supportive care.
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