Antiviral Efficacy of Pyrazofurin against Selected RNA Viruses
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
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The antibiotic pyrazofurin, -Beta-D-ribofuranosyl-4-hydroxypyrazole-5-carboxamide, markedly inhibited the in vitro replication of a number of RNA viruses including Rift Valley Fever RVF, Venezuelan equine encephalomyelitis VEE, Sandfly, Pichinde, Lassa, and LCM virus. Plaque formation was reducted by 80 or more with 2-10 microgramsml of pyrazofurin while 2 migrogramsml reduced by 1000-fold the yield of Lassa and LCM virus in a yield reduction assay. In vivo, pyrazofurin failed to protect mice and guinea pigs against a letal challenge with VEE and Pichinde virus, respectively. On the other hand, pyrazofurin caused a slight decrease in the mean time to death of mice infeced with RVF virus.