Cellular Immune Mechanisms in Malaria.
Final rept. 1 Sep 80-31 Dec 81,
WASHINGTON UNIV ST LOUIS MO SCHOOL OF MEDICINE
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The cell-mediated immune mechanisms responsible for human resistance to malaria need to be better understood. We have examined Thai adults naturally infected with malaria with regard to 1 the percentages of T, B Null and Fc receptor bearing cells present during active infection 2 the functional competence of peripheral blood mononuclear cells as judged by responsiveness to mitogens and cell surface antigens 3 the ability of serum from infected patients to supress normal lymphocyte function and 4 the incidence and nature of lymphocytotoxic antibodies in the serum of infected patients. In summary 1 in adult Thai patients naturally infected with malaria, there ia a real loss of circulating T lymphocytes with no teal change in B or Fc receptor bearing lymphocytes and with no loss of lymphocyte function as judged by mitogenic and antigenic stimulation 2 in the sera of patients infected with malaria, there are both functional suppressor capabilities and lymphocytotoxic antibodies and 3 the role of serum immuno-regulatory capabilities in modulating the immune response of infected patients may be of importance in determining the chronicity of malaria infection as well as immunologically mediated complications.
- Medicine and Medical Research