Accession Number:

ADA128434

Title:

Acute Effects of Anticholinesterase Agents on Pupillary Function.

Descriptive Note:

Final rept. 6 Jun 81-31 Dec 82,

Corporate Author:

CONNECTICUT UNIV STORRS DEPT OF BIOBEHAVIORAL SCIENCES

Personal Author(s):

Report Date:

1983-03-29

Pagination or Media Count:

16.0

Abstract:

The strategy of this investigation was to correlate closely any impairment of pupillary function to parameters of cholinergic function in vitro and in vivo, following topical or systemic administration of antiChEs. The study focused upon three aspects of cholinergic function the synthesis and turnover of ACh, the cholinergic receptor and the release of ACh. A schematic diagram of the various steps involved in the analysis of multiple parameters of acetylcholine metabolism in a single isolated iris is reported. The characteristics of the high and low affinity Ch uptake system which have been previously described for the developing and aging avian iris Marchi et al., Dev. Neurosci. 3, 185, 1980 and Brain Res. 195, 423, 1980 have now been determined for the adult rat iris.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE