The Electrophysiologic Mechanisms of Halogenated Alkane Arrhythmogenesis.
Final rept. 1 Jul 79-31 Aug 82,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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Bromochlorodifluoromethane 1211 has been shown to sensitize the myocardium to the arrhythmogenic effects of adrenergic amines. Various physiologic and pharmacologic interventions were shown to modify both FC 1211 membrane effects as well as the FC 1211 sensitization process. These interventions included alternations in potassium concentration, applying stretch to Purkinje fibers, production of hypoxic conditions, alpha adrenergic effects and beta blockage of calcium mediated slow channel effects. In studies combining cyclic nucleotide measurements with electrophysiologic parameters, it was shown that isoproterenol and FC 1211 act in an additive way to increase cyclic adenosine monophosphate levels in Purkinje fibers. Effects of FC 1211 in conscious dogs indicated that the arrhythmogenic action is due to cardiac sensitization and mediated through beta receptors. Author
- Anatomy and Physiology