Accession Number:

ADA128340

Title:

Development of Prophylactic Anti-Fungal Preparations.

Descriptive Note:

Final rept.,

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO

Report Date:

1980-10-01

Pagination or Media Count:

41.0

Abstract:

In order to develop better topical anti-fungal agents with prophylactic activity against common ringworm infection a chemical assay for sodium pyrithione a known anti-fungal drug was developed in stratum corneum and its persistence there determined a dose response study. To evaluate its effectiveness clinically a double blind trial was carried out utilizing human volunteers and experimental model for superficial fungus infection of skin. The results showed that sodium pyrithione persisted in an effective concentration in stratum corneum for 3 days after stopping application and it was concluded that an 0.5 lotion of sodium pyrithione warrants serious consideration as an alternative to Griseofulvin for prophylactic use when and if needed to combat superficial ringworm infections.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE