Development of Monoclonal Antibodies to Trypanosoma brucei rhodesiense Antigens.
Annual rept. 1 Sep 79-15 Jan 80,
NEW MEXICO UNIV ALBUQUERQUE DIV OF TROPICAL AND GEOGRAPHIC MEDICINE
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This report, describes methodology of tissue culture, hybridization procedures, immunization schedules and antibody assays developed to produce monoclonal antibodies to variant specific surface antigens of Trypansoma b. rhodesiense organisims of the Walter Reed Army Trypanozoon antigenic type WRATat serodeme. Monoclonal antibodies have been produced to WRATat 3 and 5. A laboratory has been developed for the ongoing production of monoclonal antibody reagents to Trypanosomes. These reagents will be critical in assessment of antigenic variation and in potential vaccine development programs.
- Medicine and Medical Research