Accession Number:

ADA126760

Title:

Development of Monoclonal Antibodies to Trypanosoma brucei rhodesiense Antigens.

Descriptive Note:

Annual rept. 1 Sep 79-15 Jan 80,

Corporate Author:

NEW MEXICO UNIV ALBUQUERQUE DIV OF TROPICAL AND GEOGRAPHIC MEDICINE

Personal Author(s):

Report Date:

1980-02-01

Pagination or Media Count:

21.0

Abstract:

This report, describes methodology of tissue culture, hybridization procedures, immunization schedules and antibody assays developed to produce monoclonal antibodies to variant specific surface antigens of Trypansoma b. rhodesiense organisims of the Walter Reed Army Trypanozoon antigenic type WRATat serodeme. Monoclonal antibodies have been produced to WRATat 3 and 5. A laboratory has been developed for the ongoing production of monoclonal antibody reagents to Trypanosomes. These reagents will be critical in assessment of antigenic variation and in potential vaccine development programs.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE