Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses.
Progress rept. 31 Jul 81-31 Dec 82,
OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS
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The objective of this research are to develop rapid in-vitro assays to evaluate the carcinogenic potential of chemicals used by the U.S. Air Force. Snyder-Theilen Feline Sarcoma Virus ST FeSV, quantitatively transforms human skin fibroblasts following second order kinetics. These studies were performed in order to determine whether chemicals altered ST FeSV transformation in a predictable manner and to correlate the alteration with the carcinogenic or non-carcinogenic activity of the text chemical. The results, to date, show diverse carcinogens classed as aromatic amines, polycyclic hydrocarbons, Aminofluorenes, hydrazines, asbestos and mycotoxins inhibited virus transformation when virus infected cells 2 hours post-infection were exposed to test chemical, while non-carcinogenic chemicals had no significant effect on transformation. Triton X-100, acetone, petroleum and shale oil derived JP5 RJ5 and diesel fuel, marine, demonstrated non-carcinogenic activity while formaline demonstrated carcinogenic activity. Experiments designed to show the specificity of the antagonistic effect of known carcinogens are reported.
- Medicine and Medical Research
- Biomedical Instrumentation and Bioengineering