Accession Number:

ADA126372

Title:

Preliminary Assessment of the Relative Toxicity of N,N-Dipropylcyclo-hexanecarboxamide, AI3-36326, in Laboratory Animals, November 1979 - August 1982. Phase 1,

Descriptive Note:

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Report Date:

1983-03-31

Pagination or Media Count:

20.0

Abstract:

Technical grade N,N-Dipropylcyclohexanecarboxamide was not acutely toxic by ingestion or by dermal exposure, nor did it cause any phototoxic or skin sensitization reaction. It causes slight to mild primary skin irritation and slight to mild reversible injury to the cornea and conjunctiva, both effects seeming dependent upon batch sample being tested. AI3-36326 induced enzyme production in rats with a subsequent decrease in hexobarbital sleeping time. Care should be exercised when this compound is handled in the area of the eyes. Should ocular exposure occur, rinsing the eyes with water is effective in reducing corneal irritation. Variations in skin and ocular response to different batch samples of AI3-36326 indicate the need for chemical stabilization of this chemical before proceeding with large scale chronic tests. Author

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE