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Response of Combined Electrical Stimulation and Biodegradable Ceramics.

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Final rept. 1975-1981,

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Investigations were conducted on porous tricalcium phosphate ceramic proposed for bone replacement. Rod and granular forms were studied using the ceramic alone and in combination with autogeneous bone. Animal models included mid-shaft replacements of rabbit tibiae and dog radii. The bone lesions included the initial placement of ceramic at the first surgical procedure and at nonunion sites. In general, the biomaterial analyses showed reproducible materials with porosity that permitted bone ingrowth minimal difficulties in handling the material bone ingrowth into the rod forms with biomechanical strengths similar to controls variability in the rate of resorption for the rod form ceramic minimal influence of electrical stimulation on the rate of ceramic resorption and bone ingrowth a low probability for the correction of nonunions with the rod or granular form ceramic when used alone a high probability of nonunion corrections when the ceramic was used with autogeneous bone a dependence upon the relative ratio and quantity of granular form ceramic and autogeneous bone mixtures no significant differences between -40 100 mesh or 1, 2 or 3 mm size granular materials residual ceramic retained in dog radii implant sites at 4 years and very acceptable tissue responses to the TCP material throughout this 1975 to 1981 study. Author

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research
  • Medical Facilities, Equipment and Supplies
  • Ceramics, Refractories and Glass

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