Domestic Swine in Physiological Research. IV. A Blood Acid-Base Curve Nomogram for Immature Pigs.
Interim rept. Jun-Dec 82,
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The normal acid-base characteristics of porcine blood have been poorly defined, largely because of procedural differences in animal handling, blood sampling, and measurement techniques. Consequently, 40 immature, 20- to 31 kg domestic pigs were used to establish population characteristics for arterial blood. Samples were collected from chronically implanted catheters while the animals were maintained under steady state, near-basal conditions. Hourly measurements over a 6-hour period in 6 of these pigs showed a small but significant decrease in P 02, with time but no significant change in acid-base status. The data showed that nomograms or other procedures based on human blood characteristics were invalid when used to estimate base excess concentration of porcine blood. The normal pH of arterial blood was higher in pigs than in humans hence, parameters defining zero base excess differed in the two species. Consequently, constant P C02 titrations were performed on arterial samples taken from 10 pigs and the data were used to construct an acid-base curve nomogram in which zero base excess was defined for blood with a pH of 7.50 and a P CO2 of 40 torr.
- Anatomy and Physiology