Fourteen-Day Feeding Study of 2,4-Dinitrotoluene in Male and Female Rats
Final rept. 18 Feb-25 Mar 1981
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The purpose of this study was to obtain preliminary data in rats concerning effects of 2,4-dinitrotoluene DNT on tissue histology, blood chemistry, hematology, and urinary parameters. Male and female rats were fed a laboratory chow diet to which was added 0, 1.0, 1.5, 2.5, and 3.5 g DNTkg. After 14 days, the animals were fasted in metabolic cages, killed, and necropsies were performed. No DNT-related effects were found on blood hematology or urinary parameters. Blood cholesterol was elevated in all groups receiving DNT. A dose-dependent elevation in blood glucose was observed in both sexes, but the effect was statistically significant only in the females. Alanine aminotransferase was elevated in all male groups fed the compound. DNT induced the development of hyaline droplets in the epithelium of the proximal convoluted tubules of the kidneys of both males and females. Oligospermatism with degenerative changes in the testes of male rats was observed in a dose-dependent response.