Toxicity Studies of Formaldehyde Monomethylhydrazone
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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The toxicity of formaldehyde monomethylhydrazone FMH has been studied. The LD50 of FMH in the mouse was 42 mgkg. Signs of acute toxicity were tremors and violent convulsions. Pyridoxine effectively prevented these convulsions. Reaction of FMH and DMBA appears similar to monomethylhydrazine MMH suggesting past errors in quantitating MMH using the spectrophotometric method. The high dose group 20 mgkg of mice in the short term toxicity study had an elevated serum aspartate aminotransferase SGOT but did not develop demonstratable histopathologic lesions involving the liver.
- Organic Chemistry