Topical Hazard Evaluation Program of Candidate Insect Repellents, AI3-36976a, 36977a, 37013a, 37014a, 37015a.
ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD
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Preliminary hazard evaluations of the above candidate insect repellent chemicals were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. Chemicals AI3-36976a, 36977a, 37013a, 37014a, and 37015a caused mild primary skin irritation. Chemicals AI3-36976a, 36977a, 37013a, 37014a, and 37015a were noninjurious to the eyes of rabbits. All chemicals were relatively non-toxic by ingestion. Chemicals AI3-36976a, 36977a, 37013a, 37014a, and 37015a caused photo irritation in rabbits. All chemicals did not prove to be skin sensitizers. It is recommended that all chemicals be disapproved for further testing as candidate insect repellents due to their photo-irritation potentiating properties.