Accession Number:

ADA125214

Title:

Dermal Penetration and Distribution of 14C-Labeled N,N-Dipropylcyclohexane Carboxamide, AI3-36326 Study, May-October 1982. Phase 2.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

• Snodgrass,Hubert L. , Jr

Report Date:

1983-03-01

Pagination or Media Count:

13.0

Abstract:

The candidate insect repellant N,N-dipropylcyclohexane carboxamide was assessed for absorption potential in rabbits and dogs by monitoring radiocarbon in excrets for 7 days following a single application. In both species, absorption occured primarily in the first 24 hours and measured 26 percent of the applied dose in rabbits and 12 percent in dogs through 7 days. No bioaccumulation in tissue specimens was noted at necropsy by this route. Absorption in man should be less than 10 percent of the applied dose. Author

Descriptors:

• *TOXICITY
• *SKIN(ANATOMY)
• *INSECT REPELLENTS
• PENETRATION
• DOSAGE
• ABSORPTION
• DOGS
• LABELED SUBSTANCES
• RADIOACTIVE ISOTOPES
• RABBITS
• TRACER STUDIES
• EXCRETION

Subject Categories:

• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE