Accession Number:

ADA123269

Title:

Studies on the Enzymatic Hydrolysis of Organophosphate Poisons in Pigs.

Descriptive Note:

Final rept. May 81-Jul 82,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s):

Report Date:

1982-11-01

Pagination or Media Count:

31.0

Abstract:

Phosphate paraoxon was studied in Yorkshire pig, rat and human sera. Enzymatic hydrolysis was significantly affected by certain buffers in the reaction mixture. Kinetic measurements suggest that more than one enzyme hydrolyzes the organophosphate. Depending on pH and substrate concentration, inhibition of the enzymes by paraoxon is or is not observed. Enzymatic activity in human serum increases with a rise in pH whereas in pig serum activity decreases. Author

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE