Studies on the Enzymatic Hydrolysis of Organophosphate Poisons in Pigs.
Final rept. May 81-Jul 82,
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Pagination or Media Count:
Phosphate paraoxon was studied in Yorkshire pig, rat and human sera. Enzymatic hydrolysis was significantly affected by certain buffers in the reaction mixture. Kinetic measurements suggest that more than one enzyme hydrolyzes the organophosphate. Depending on pH and substrate concentration, inhibition of the enzymes by paraoxon is or is not observed. Enzymatic activity in human serum increases with a rise in pH whereas in pig serum activity decreases. Author