Molecular Toxicology of Chromatin
Progress rept. Oct 1981-Sep 1982
CALIFORNIA UNIV SAN FRANCISCO DEPT OF PHARMACOLOGY
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The patho-biological function of the nuclear homopolymer poly ADP- ribose is being studied. It was found that this homopolymer, that has been identified recently by us to be a unique nucleic acid, with helical conformation, and is covalently bound to prevalently non histone chromatin proteins, exhibits specific quantitative signals during aging differentiation and precancerous perturbations.
- Medicine and Medical Research