Accession Number:

ADA123222

Title:

Molecular Toxicology of Chromatin

Descriptive Note:

Progress rept. Oct 1981-Sep 1982

Corporate Author:

CALIFORNIA UNIV SAN FRANCISCO DEPT OF PHARMACOLOGY

Personal Author(s):

Report Date:

1982-09-01

Pagination or Media Count:

16.0

Abstract:

The patho-biological function of the nuclear homopolymer poly ADP- ribose is being studied. It was found that this homopolymer, that has been identified recently by us to be a unique nucleic acid, with helical conformation, and is covalently bound to prevalently non histone chromatin proteins, exhibits specific quantitative signals during aging differentiation and precancerous perturbations.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE