Investigations of Cross Immunity between Leishmania tropica (Jericho) and Leishmania braziliensis in Experimentally Infected Mystromys albacaudatus.
Final rept. Feb 79-Jan 81,
VIRGINIA UNIV CHARLOTTESVILLE DEPT OF DERMATOLOGY
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The purpose of this report is to bring to attention the results of investigations dealing with possible cross immunity between L. tropica and L. braziliensis panamensis in an animal model. At this point in time, it would appear that there is some evidence that cross immunity does exist utilizing M. albacaudatus as an animal model. If suitable experimental animals are successfully vacinated with promastigotes of L. tropica jericho solid immunity will develop to challenge L. braziliensis or L. braziliensis panamensis Part of this hypothesis is supported by the work of Lainson and Bray 1966 as mentioned above and part by the rich history of the use of related species of parasites or species with reduced virulence to prevent disease.
- Medicine and Medical Research