Toxicity Studies on Antiradiation Agents.
HAZELTON LABS AMERICA INC VIENNA VA
Pagination or Media Count:
This contract was awarded to provide for the conduct of toxicological evaluations on various drugs under study by WRAIR. In general, these acute and subacute studies were designed to evaluate and characterize the pharmacotoxic signs of these drugs to support the IND. Eighteen studies were performed over the period of this contract. WR-2823 AU 69115 was evaluated for acute oral toxicity by oral intubation to three groups of two male rats each at dosage levels of 100, 1000, and 10,000 mgkg of body weight acute oral dose range in order to more accurately define the toxic range prior to initiating an expanded LD50 study. WR-2823 AU 69115 was then further evaluated for acute oral toxicity by oral intubation to eight groups of 10 male rats each at dosage levels of 100 to 2150 mgkg of body weight. The acute oral LD50 was found to be 2037 mgkg of body weight confidence limits, 1281 to 3239 mgkg of body weight. Signs of toxic effect included depression, labored respiration, hunched appearance, diarrhea or brown stains on body, squinting, ptosis, lacrimation, reddened eyes, yellow stain on fur, urine stain, and slight ataxia.