Artificial Red Cells with Polyhemoglobin Membranes.
Final rept. 1 Oct 80-30 Jun 81,
EXXON RESEARCH AND ENGINEERING CO LINDEN N J
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Artificial red cells were prepared with polyhemoglobin membranes. Red-cell-size microdroplets containing 30 of hemoglobin were held in liquid membrane capsules and treated with glutaraldehyde that cross linked the hemoglobin at the surface of each microdroplet. A water-soluble surfactant was used to eject the cells from the oil and suspend them in saline. The hemoglobin was retained by the artificial red-cell membrane, but biotonometry revealed that it held oxygen more tenaceously after encapsulation. Author