Pharmacological Studies on Clostridial Neurotoxins.
Annual Rept. No. 1, 1 Nov 81-31 Aug 82
COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS
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Experiments have been done that compare the actions of botulinum toxin type A, tetanus toxin, diphtheria toxin and beta-bungarotoxin on the cholinergic neuromuscular junction. All four toxins bind to tissues without producing adverse effects each of the toxins has its own unique class of receptors. After tissue binding has occurred, botulinum toxin, tetanus toxin and diphtheria toxin are internalized this process is antagonized by chloroquine, ammonium chloride and methylamine hydrochloride. Beta-Bungarotoxin is not internalized and is not antagonized by the drugs just listed. Diphtheria toxin acts intracellularly to ADP-ribosylate elongation factor 2. The intracellular actions of botulinum toxin and tetanus toxin have not been determined.