Response of Combined Electrical Stimulation and Applied Laboratory and Clinical Studies on Biodegradable Ceramic.
Annual rept. no. 5, Jul 79-Nov 80,
ALABAMA UNIV IN BIRMINGHAM
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Investigations on granular 1, 2 or 3 mm average size and rod 1 cm diameter x 1 cm length form porous tricalcium phosphate ceramic has shown good biocompatibility in rabbit and dog animal models. The granular form was mixed with equal weights of autogenous bone and 8 mm tibial lesions in rabbits evaluated at 3, 6 and 9 months post surgery. Twenty three of twenty five comparable sites healed and showed no specific correlation with ceramic particulate size. Rod form ceramic implants in the mid position of dog radii showed continued biodegradation at healed and nonunion sites. Initial human clinical investigations for the granular form ceramic with autogeneous bone should initiate in 1981. Author
- Medicine and Medical Research