Accession Number:

ADA113586

Title:

Dermal Sensitization Potential of Candidate Insect Repellents: LAIR Formulation (CHF1) N-(n-octyl) glutarimide (CHR2) N-(n-hexyl) glutarimide (CHR3) (E) 1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl)quinoline (CHR5) 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-oxo-2-butenyl) quinoline (CHR6).

Descriptive Note:

Final rept. 22 Apr-8 Jun 81,

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s):

• Fruin,John T.
• Hanes,Martha A.
• Black,Kenneth
• Gildengorin,Virginia L.

Report Date:

1982-02-01

Pagination or Media Count:

41.0

Abstract:

Arthropods represent a potential disease threat to U.S. Military Forces consequently, a program to develop improved insect repellents was developed. The dermal sensitization potential of candidate insect repellents was determined using guinea pigs. Test substances CHF1, CHR2, and CHR3 were clearly non-sensitizing. CHR5 and CHR6 were irritating, possibly sensitizing, and should be retested. Author

Descriptors:

• *Insect repellents
• *Toxicity
• *Quinolines
• Sensitivity
• Skin(Anatomy)
• Skin tests
• Guinea pigs
• Molecular structure

Subject Categories:

• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE