Accession Number:

ADA113089

Title:

The Synthesis and Evaluation of 15-Keto-PGB1 Analogs.

Descriptive Note:

Annual technical rept. no. 2, 1 Mar 81-1 Mar 82,

Corporate Author:

SAINT JOSEPH'S UNIV PHILADELPHIA PA DEPT OF CHEMISTRY

Personal Author(s):

Report Date:

1982-03-01

Pagination or Media Count:

24.0

Abstract:

The initial reaction pathway for the oligomerization of 15-dehydro-PGB1 was determined by the investigation of structurally simpler analogues. This information was used to 1 provide structural insights into the complex oligomeric mixture termed PGBx, 2 develop mild reaction conditions for the conversion of 15-dehydro-PGB1 into less complicated oligomeric mixtures still retaining mitochondrial activity, and 3 design structural modifications that would result in the formation of less complicated oligomeric mixtures that still retain the unique mitochondrial protective effect. Author

Subject Categories:

  • Polymer Chemistry
  • Plastics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE