Laser Desorption Mass Spectrometry. II. Applications to Structural Analysis.
PITTSBURGH UNIV PA DEPT OF CHEMISTRY
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Laser desorption mass spectrometry LDMS is reviewed with focus on application to structural analysis of nonvolatile organic compounds. Models for the ionization-volatilization step are discussed with reference to solid-state vs. gas-phase reactions. General characteristics of LDMS of organic compounds are discussed for example, classes of compounds that generate M ions or MH ions. Cationization reactions are considered organic salts are discussed. Particular emphasis is placed on LDMS of high molecular weight compounds such as polysaccharides, polymers and vitamin B12 and its relatives. Problems of ion-molecule reactions complicating spectra are considered, particularly for transition metal coordination compounds. Other topics considered include quantitative analysis, microprobe applications and sample handling. Author
- Lasers and Masers
- Atomic and Molecular Physics and Spectroscopy