Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization
Interim technical rept. Feb-Aug 1980
CALIFORNIA UNIV DAYTON OH
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Comparison was made of three skin sensitization procedures Landsteiner, Maguire, and Guinea Pig Maximization. Dinitrochlorobenzene, formaldehyde and Carbowax 4000 were selected as strong, weak to moderate, and non-sensitizers, respectively. The Maguire Test was most consistent in detecting the effects of these materials in the predicted order. Micropathologic examination of tissue at application sites did not increase the accruacy or precision of the tests.