Accession Number:

ADA110633

Title:

Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

Descriptive Note:

Interim technical rept. Feb-Aug 1980

Corporate Author:

CALIFORNIA UNIV DAYTON OH

Report Date:

1981-11-01

Pagination or Media Count:

18.0

Abstract:

Comparison was made of three skin sensitization procedures Landsteiner, Maguire, and Guinea Pig Maximization. Dinitrochlorobenzene, formaldehyde and Carbowax 4000 were selected as strong, weak to moderate, and non-sensitizers, respectively. The Maguire Test was most consistent in detecting the effects of these materials in the predicted order. Micropathologic examination of tissue at application sites did not increase the accruacy or precision of the tests.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE