A Preliminary Report on the Osteogenic Potential of a Biodegradable Copolymer of Polylactide: Polyglycolide (PLA:PGA).
Manuscript for publication Jul-Dec 81,
ARMY INST OF DENTAL RESEARCH WASHINGTON DC
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A biodegradable copolymer of 5050 polylactidepolyglycolide was prepared for implantation into experimentally created osseous defects in the tibias of 25 rats. Similarly prepared defects were made in the humeri and these did not receive copolymer implants. At 7, 14, 21, 28, and 42 days five animals were sacrificed and the implant and untreated sites were evaluated by gross visual inspection and by histologic examination using a Zeiss Videoplan Image Analysis System with Osteoplan for the quantitation of bone morphometrics. When compared with bony defects that were not treated with the biode-gradable copolymer implant, the implant sites displayed a slightly accelerated healing response rate at 7 days p0.01, a slightly accelerated response rate at 14 and 21 days p0.005, and a similar healing response rate at 28 and 42 days p0.01. The copolymer was highly tissue tolerant throughout the period of the investigation. Author
- Medicine and Medical Research