Effect of 'Streptococcus Pneumoniae' Infection in Rats on Hepatic Water Content, Electrolyte Concentration, and Chemical Composition
ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD
Pagination or Media Count:
Total hepatic water content, dry weight, protein, lipid, carbohydrate, RNA, DNA, and electrolyte concentrations were determined in control and Streptococcus pneumoniae-infected rats. During infection, there was a significant P 0.001 increase in total liver weight. This increase was the result of increased total liver water content, diameter of hepatocytes, and all measured constituents of hepatic dry weight, excluding DNA, increased significantly P varied from 0.05-0.001 during infection. Concentrations of liver Na and Cl- increased significantly P varied from 0.05-0.005, whereas the concentration of liver K decreased significantly P 0.01. Seemingly, there is an enlargement of hepatocytes due to increased intracellular water and increased dry weight during pneumococcal infection in the rat. The mechanism of these liver changes may be due, in part, to a shift of Na and K across liver cell plasma membranes.
- Medicine and Medical Research