Equilibrium Performance Changes Produced by Atropine in M. mulatta and M. fascicularis.
Final rept. Jun-Dec 80,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX
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Two species of monkeys were trained to maintain a primate equilibrium platform in a relatively horizontal position by a control stick. Once asymptotic performance was achieved, animals received intramuscularly a saline control injection or 0.105, 0.140, 0.197, or 0.250 mgkg, in randomized order, of atropine sulfate. The animals performance was then observed for 3.5 hours. A statistically significant ordering of drug effects was seen, but no differences between species. Atropine produced no effect at the 0.105-mgkg dose, but marked performance decrements were measured after the 0.250-mgkg dose. Author
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