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Environmental Fate and Effects of N-phenyl-1-Naphthylamine and Its Disposition and Metabolism in the Rat.

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Final rept.,

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The photolysis of N-phenyl-1-naphthylamine PNA in aqueous solutions has been studied under natural sunlight as well as under laboratory conditions. Photodegradation of the material in sunlight is rapid and proceeds with a half-life of 5-8 minutes. The rate is, however, influenced by oxygen, and considerably enhanced rates are obtained in deoxygenated solutions. Photolysis in aerated solutions appears to lead to one primary product. This material is relative photostable, inert to sensitization by humic acid, and may also be prepared by photolysis of PNA in nonaqueous solvents. Preliminary spectral data indicates that it may be the aniline adduct of 1,4-naphthoquinone. PNA is degraded by microorganisms in lake water with a disappearance half-life of approximately 10 days. The acute toxicity of PNA to rainbow trout, bluegill sunfish and Daphnia magna was determined under static and flow-through exposure conditions. The chronic toxicity of the PNA to Daphnia magna was determined under static-renewal exposure conditions. The uptake and elimination of 14-C-PNA by bluegills was investigated in preliminary short-term static exposure experiments and in a definitive flow-through experiment. The uptake and elimination of the 14-C-PNA by Daphnia magna was also investigated in a static test. Preliminary results indicate that exposure to rainbow trout to sublethal concentrations of PNA may affect the feeding behavior of the fish. The absorption, tissue distribution, excretion, and metabolism of PNA was studied in the male rat following oral administration.

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  • Toxicology

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