Accession Number:

ADA106725

Title:

Heat-Induced Changes in Perfused Rat Liver,

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1981-09-28

Pagination or Media Count:

17.0

Abstract:

In order to determine the time periods at which heat-induced structural changes occurred, isolated rat livers were perfused for different time intervals at 41 - 43 C with oxygenated Krebs-Ringer bicarbonate containing .14 glucose. Structural changes occurred after 60 minutes at 41 C, 30-45 minutes at 42 C and 15 minutes at 43 C. Under these perfusion conditions, structural changes were detected before bile production or enzyme leakage reflected changes. The data suggest a continuum of events depending on the time and temperature of exposure, leading to the same end point loss of endothelium, vacuolization, loss of microvilli, and formation of flocculent densities in mitochondria. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE