Histocompatibility Typing for the Prediction of Susceptibility to Infectious Disease.
Annual rept. 1980-1981,
GEORGETOWN UNIV WASHINGTON D C DEPT OF PEDIATRICS
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The objective of this contract is to determine if susceptibility to certain infectious agents or morbidity associated with infection can be predicted based on knowledge of HLA type. The contract was established to design and conduct studies that will indicate if one can predict an individuals ability to mount an immune response to an active infection causing disease or to a practical vaccine based on a knowledge of genes within the HLA region. The population chosen for the index study comprises individuals who as infants suffered respiratory syncytial virus RSV infection, where a small number developed bronchiolitis requiring hospitalization while most recovered with no severe side effects. Association andor linkage between HLA, virus infection seroconversion and morbidity bronchiolitis as well as a number of other factors has been evaluated within the random sample population and within families using standard statistical methods.
- Medicine and Medical Research