Accession Number:

ADA104053

Title:

Unique Effects of Infectious or Inflammatory Stress on Fat Metabolism in Rats.

Descriptive Note:

Interim rept.,

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FREDERICK MD

Personal Author(s):

• Neufeld,Harold A.
• Pace,Judith G.
• Kaminski,Mitchell V.
• Sobocinski,Philip Z.
• Crawford,Daniel J.

Report Date:

1981-08-07

Pagination or Media Count:

45.0

Abstract:

Infectious or inflammatory stress in the rat causes very typical functional and metabolic alterations. Among the most typical are elevation in body temperature, plasma copper, insulin, and glucagon and depression in the concentration of plasma ketones, free fatty acids and zinc. These changes occur only with infectious or inflammatory stress and not with noninflammatory stresses such as femoral fracture, screen restraint or exercise. It appears that the depression in plasma ketone bodies during infection or inflammation is closely related to the rise in plasma insulin. During infection imposed on experimentally induced diabetes, inhibition of plasma ketones is no apparent. In a similar fashion, infection in hypophysectomized rats causes no elevation in plasma insulin and no depression in plasma ketones. Discussion concerning the implications of these observations in the rat and primate is included. Author

Descriptors:

• *METABOLISM
• *FATS
• *INFECTIOUS DISEASES
• *INFLAMMATION
• RATS
• STRESS(PHYSIOLOGY)
• COPPER
• ZINC
• BLOOD PLASMA
• KETONES
• INSULIN
• BODY TEMPERATURE
• FATTY ACIDS
• GLUCAGON

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE