Accession Number:

ADA102177

Title:

In Vitro Chemical Carcinogenesis and Co-Carcino-genesis in Human Cells Initiated by Hydrazine and Polynuclear Components of Jet Fuel

Descriptive Note:

Final rept. 1 Jul 1977-30 Jun 1980

Corporate Author:

OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s):

Report Date:

1980-09-01

Pagination or Media Count:

243.0

Abstract:

Examination of the carcinogenic activity of selected hydrazine, polynuclear hydrocarbons andor napthylamines on human cells was evaluated on human foreskin cell populations in vitro. We also evaluated the interaction of these compounds with feline oncornaviruses ST-FeSV. To date we understand how this system can be used to evaluate the carcinogenic activity of the above suspected carcinogens. We have listed the chemicals evaluated in this system for their carcinogenic activity. Table 4 presents characteristics of the transformed cells in early, transitional and late stages of the carcinogenic process. The contents to Table 2 Segment 2 summarizes the comparative aspects of the carcinogenic activity and cocarcinogenic activity of the chemicals. In Table 2 Segment 2 it was found that RDDP activity was absent in the carcinogen transformed cells. We can conclude from these data that the induction of the carcinogenic process is not a consequence of indogenous oncornavirus activation. These data presented to date illustrate that human cells can be used to evaluate carcinogens and cocarcinogens on human cells.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE