Neuronal Adaptive Mechanisms Underlying Intelligent Information Processing
Final scientific rept.
CALIFORNIA UNIV MEDICAL CENTER LOS ANGELES
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By means of this grant, advances were made in 1. Identifying key features controlling adaptation in neural networks. 2in. Developing and calibrating a device for pressure injection of minute volumes through fine micropipettes. 3. Examining, intracellularly, the response of single cortical neurons to a. a behavioral unconditioned stimulus used to produce conditioned behavior b. an unconditioned stimulus produced by direct electrical activation, antidromically, of single, pyramidal tract neurons and c. direct application of pharmacologic agents thought to cause neural adaptation. 4. Simulating adaptive features of single neurons. 5. Altering rates of acquisition of conditioned behavior by direct neuromodulatory procedures. The results have led to an improved understanding of neuronal adaptive mechanisms underlying intelligent information processing by the brain and afford the design of improve components for use in artificial intelligence.