Metabolism of Hydrazine
Final rept. 1 Oct 1979-30 Sep 1980
OREGON STATE UNIV CORVALLIS DEPT OF AGRICULTURAL CHEMISTRY
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In rats exposed to atmospheric hydrazine, the log of blood hydrazine concentration was found to bear a more or less linear relation to atmospheric hydrazine levels. At 20-25 mg hydrazinecu M, blood concentrations approached 100 nmoleml, and were about 2 nmoleml at atmospheric concentrations of about 3 mgcu M. During exposure, blood concentrations tended to rise rather quickly in the first hour, then oscillated slowly around a generally constant level throughout six hours of exposure. Blood concentration of hydrazine following a single 1 nmolekg dose decreased with a first phase halftime of about 45 minutes followed by a slower decrease with halftime of 27 hours. Less than one percent of such doses was excreted in bile. In vitro reaction of 5 m molar hydrazine in whole blood proceeded at a rate of about .016 micromolem1minute or about 10 in 30 minutes. With higher concentrations turnover becomes more rapid and can exceed the hemoglobin subunit equivalence by many fold. Extensive efforts to locate 15Nlabelled urinary metabolities that would account for remaining uninventoried hydrazine have not yet succeeded.
- Anatomy and Physiology