Chronic Inhalation Toxicity of Hydrazine: Oncogenic Effects
CALIFORNIA UNIV DAYTON OH
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Year-long exposures of animals were conducted to hydrazine in the listed concentrations 0.05, 0.25, 1.0, 5.0 ppm - rats and hamsters 0.05 0.25, 1.0 ppm - mice and 0.25, 1.0 ppm - dogs. Hamsters were held one year postexposure, rats - 18 months postexposure, mice - 15 months postexposure and dogs - 38 months postexposure. Hamsters exposed to the higher concentration showed pathologic changes characteristic of degenerative disease while rats exhibited changes in respiratory epithelium related to chronic irritation. After exposure to 5.0 ppm hydrazine, hamsters developed a 10 incidence of benign nasal polyps compared to 0.5 in controls. Male and Female rats showed dose- dependent incidences of microscopic benign epithelial nasal tumors and small numbers of microscopic malignant epithelial nasal tumors after one year exposure to hydrazine and 18 months postexposure holding.
- Anatomy and Physiology