The Teratogenic Effects of the Fuel JP-10 on the ICR Mice.
INDIANA UNIV-PURDUE UNIV AT FORT WAYNE
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JP-10 is a synthesized fuel for Cruise Missiles. It is the exoisomer of 4, 7-methano-1H-indene, octahydro 12a alpha, 4 alpha, 7 alpha, 7a alpha, CA 2825-83-4. Pregnant ICR mice were given oral doses of 0.2, 0.4, 0.6 and 0.8 mlkg on days 6 through 9 of gestation. No significant differences were found between controls and experimental groups in mean implantsfemale, mean viable fetuseslitter, mean resorptionslitter, frequency of resorptions, frequency of soft tissue anomolies and frequency of skeletal anomalies. Mean fetal weight was significantly heavier in the 0.2 and 0.4 mlkg groups. This effect is difficult to explain when the 0.6 and 0.8 mlkg groups showed no increase in fetal weight. Author